Mar. 2025 – Enzyme Discovery and In Vivo Assessment
Plant-Derived UDP-Glycosyltransferases for Glycosylation-Mediated Detoxification of Deoxynivalenol: Enzyme Discovery, Characterization, and In Vivo Resistance Assessment . March 2025, Copenhagen - In a paper published in Toxins, DTU (Danish Technical University) and River Stone researchers used River Stone’s 380-member large UGT (UDP-glucose dependent glycosyltransferases) library (Gly-it.com) to identify 8 novel UGTs that could efficiently glycosylate the harmful toxin deoxynivalenol (DON). DON is found in, e.g., Rice, maize, wheat, and barley infected with the plant pathogenic fungus Fusarium graminearum. DON also being toxic to plants these respond by glycosylating the molecule, thereby achieving at least part detoxification. As it is crucial to avoid contamination...
Jul. 2024 – Glycosylation of aloesone
Enzymatic glycosylation of aloesone performed by plant UDP-dependent glycosyltransferases . In a paper published in Glycobiology, researchers of the Danish Technical University (DTU) and River Stone demonstrates that a high number of natural UGTs (UDP-glucose dependent glycosyltransferases) are able to glycosylate the plant molecule aloesone. Aloesone and its derivatives are highly used in cosmetics, and therefore the findings from this work may be very important for this field to progress. For this collaborative program River Stone supplied its 380-member large UGT library, which is commercially available as kit and service, Gly-it.com. https://pmc.ncbi.nlm.nih.gov/articles/PMC11273223/ . ...
Dec. 2023 – Global commercial launch
Advancing to global commercial launch . Cambridge, December 18, 2023 – River Stone Biotech Inc.(RSB), a synthetic biology business centered around a disruptive specialty API offering, today announced the issuance of a U.S. Patent covering a key family of enzymes enabling preparation of precursors to high value compounds such as buprenorphine, naloxone, naltrexone, and nalmefene. These enzymes are key to enabling a process that is higher efficiency and uses more environmentally-friendly reagents than conventional production methods. This production approach works synergistically with RSB’s proprietary chemistry methods, as described in previously granted US 11,390,628 and AU 2018268173, to generate these high value APIs. U.S. Patent...