Plant-Derived UDP-Glycosyltransferases for Glycosylation-Mediated

Detoxification of Deoxynivalenol: Enzyme Discovery, Characterization,

and In Vivo Resistance Assessment

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March 2025, Copenhagen – In a paper published in Toxins, DTU (Danish Technical University) and River Stone researchers used River Stone’s 380-member large UGT (UDP-glucose dependent glycosyltransferases) library (Gly-it.com) to identify 8 novel UGTs that could efficiently glycosylate the harmful toxin deoxynivalenol (DON). DON is found in, e.g., Rice, maize, wheat, and barley infected with the plant pathogenic fungus Fusarium graminearum. DON also being toxic to plants these respond by glycosylating the molecule, thereby achieving at least part detoxification. As it is crucial to avoid contamination with DON and similar molecules in food and feed, the identification of new and better DON UGTs may be a very important contribution to food safety for the future.

https://www.mdpi.com/2072-6651/17/4/153

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