Sample Page – Riverstonebio

Revolutionizing

SMALL MOLECULE PHARMA

WITH SYNTHETIC BIOLOGY

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River Stone uses synthetic biology to enable new pharmaceutical approaches.
We are focused on three areas

CNS

Rethinking how CNS actives are made, in particular molecules for treating addiction

IN SITU

Making small molecule APIs inside the body. Enables entirely new ways of treating disease

GLY-IT

Altering small molecule ADMET and tissue distribution via saccharide decoration

CNS ACTIVES

Enabling simpler routes to the

manufacture of CNS active APIs

Many CNS actives have challenging manufacturing routes

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Synthetic biology can improve these in multiple ways

IN SITU

MAKING SMALL MOLECULE

DRUGS INSIDE THE PATIENT

Making APIs local to the site of the disease

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– and making the right amount at the right time

– can open up multiple new ways to treat disease

GLY-IT

GLYCOSYLATION

OF SMALL MOLECULES

Glycosylation can significantly enhance

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We provide a range of products and services

the properties of small molecules

to open up this space for you

PIONEERING SYNTHETIC BIOLOGY

River Stone was founded in 2016 with a focus on API production route re-engineering. Our team has a track record in building pioneering synthetic biology and life science ventures. The team has brought multiple synbio and pharma products to market.

SENIOR TEAM

Paul Goldenheim

CEO

Paul is trained as a pulmonary physician and is currently working as a director and consultant in the field of biotechnology, serving on the boards of directors of several companies including Adenium, and Hydra Biosciences. Paul has a long history in pharmaceutical research, development, and management, most recently as President of TransForm Pharmaceuticals (acquired by Johnson & Johnson) and Vice-Chairman of the Board of Directors of Hypnion (acquired by Eli Lilly). Paul also serves on the board of directors of Celebrity Series of Boston. Dr. Goldenheim received his AB from Harvard College magna cum laude with highest honors in biochemical sciences and his MD from Harvard Medical School.

Neil Goldsmith

CBO

From 2004 to 2017, Neil was co-founder, CEO and board member of Evolva SA, taking it from a startup biotech venture to a leading synthetic biology company listed on the Swiss stock exchange. He was previously a co-founder of Topotarget A/S, which is listed on the Copenhagen exchange, and of Personal Chemistry AB, which became Biotage AB, and is listed on NASDAQ Stockholm. Prior to that he held management roles in Phytera Inc, PNAD A/S and Biacore AB, amongst other life science ventures. He is a board member of Unibio International plc, Double Bioventures Ltd, and Prospero Biotech Ltd.

Paula Hicks, SVP Technology & IP

SVP Technology & IP

Paula has 20 years of technology expertise in diverse industries utilizing biotechnology. From 2011 to 2018 Paula held several senior technical leadership roles at Evolva, Inc. successfully scaling up multiple projects and managing programs with industrial, university, and government partners. Prior to that she served as a technical program manager for biopharmaceutical projects at Bend Research, Inc. (now Lonza). Hicks started her career at Cargill leading development of new processes for food ingredients. She holds a Ph.D. in Chemical Engineering from North Carolina State University.

Tim Bowser

CDO

30+ years in GSK & Sun Pharma – R&D, BD, GM & API roles. Took opiate alkaloid products from lab to market. 3 Science papers on poppy API biosynthesis, B.A.Sc. Chemistry.

Jørgen Hansen

CSO, CEO Denmark

From 2013-2018, Jørgen served as Evolva’s Chief Scientific Officer, running a five-site R&D organization with the full complement of synthetic biology, from idea stage and bioinformatics over strain development to scale-up of upstream and downstream processes. Before that and since 2005, he has directed the activities of the Evolva Copenhagen laboratory. Previously he worked at Poalis Biotech, a biotech startup from University of Copenhagen, Carlsberg Laboratory, the Danish Technical University and Aarhus University.

Esben Halkjær Hansen

VP, R&D

Esben has 14 years of experience within microbial production strain development, pathway discovery, and optimization. From 2011-2017, Esben served as Program Manager at Evolva, running several different strain development programs and has successfully brought projects from idea phase, over strain optimization to production. Previously he has worked at Poalis Biotech. He has a PhD in Molecular Biology/Pharmaceutical Science from University of Copenhagen.

CONTACT AND INFORMATION

For questions regarding commercial partnerships and investors and collaboration with academic partners, please contact us. Feel free to call on us anytime.

Extensive experience in making,

WE HAVE A FULL SUITE OF

SYNTHETIC BIOLOGY CAPABILITIES

Our team has taken multiple products

from idea to commercial launch

scaling and launching

River Stone uses synthetic biology to enable new pharmaceutical approaches.
We are focused on three areas

CNS

Rethinking how CNS actives are made, in particular molecules for treating addiction

READ MORE

IN SITU

Making small molecule APIs inside the body. Enables entirely new ways of treating disease

READ MORE

GLY-IT

Altering small molecule ADMET and tissue distribution via saccharide decoration

READ MORE

PIONEERING SYNTHETIC BIOLOGY

River Stone was founded in 2016 with a focus on API production route re-engineering. Our team has a track record in building pioneering synthetic biology and life science ventures. The team has brought multiple synbio and pharma products to market.

READ MORE

SENIOR TEAM

CONTACT AND INFORMATION

For questions regarding commercial partnerships and investors and collaboration with academic partners, please contact us. Feel free to call on us anytime.

READ MORE

River Stone Biotech INC.

River Stone Biotech ApS

River Stone Biotech PTY LTD

CONTACT

River Stone uses synthetic biology to enable new pharmaceutical approaches. We are focused on three areas

CNS

Rethinking how CNS actives are made, in particular molecules for treating addiction

READ MORE

IN SITU

Making small molecule APIs inside the body. Enables entirely new ways of treating disease

READ MORE

GLY-IT

Altering small molecule ADMET and tissue distribution via saccharide decoration

READ MORE

PIONEERING SYNTHETIC BIOLOGY

River Stone was founded in 2016 with a focus on API production route re-engineering. Our team has a track record in building pioneering synthetic biology and life science ventures. The team has brought multiple synbio and pharma products to market.

READ MORE

SENIOR TEAM

Paul Goldenheim

CEO

Neil Goldsmith

CBO

Paula Hicks, SVP Technology & IP

SVP Technology & IP

Tim Bowser

CDO

Jørgen Hansen

CSO, CEO Denmark

Esben Halkjær Hansen

VP, R&D

CONTACT AND INFORMATION

For questions regarding commercial partnerships and investors and collaboration with academic partners, please contact us. Feel free to call on us anytime.

READ MORE

River Stone uses synthetic biology to enable new pharmaceutical approaches.
We are focused on three areas