River Stone Biotech has a strong IP portfolio, with two granted patents and numerous applications in progress

  1. United States Patent 11,390,628 – Preparation of Buprenorphine
  2. United States Patent 11,060,071 – Increased biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors in a recombinant host cell
  1. Hudlicky, T., 2015. Recent advances in process development for opiate-derived pharmaceutical agents. Canadian Journal of Chemistry, 93(5), pp.492-501.
  2. World Health Organization, 2020. International standards for the treatment of drug use disorders: revised edition incorporating results of field-testing. Geneva. WHO
  3. UNODC-WHO, 2008. Principles of Drug Dependence Treatment. (V.09-87723 ). Vienna: UNODC.
  4.  Leshner, A.I., 1997. Addiction is a brain disease, and it matters. Science, 278(5335), pp.45-47
  • Richards, L., Jarrold, A., Bowser, T., Stevens, G.W. and Gras, S.L., (2020). Cytochrome P450-mediated N-demethylation of noscapine by whole-cell biotransformation: process limitations and strategies for optimisation. Journal of Industrial Microbiology and Biotechnology, 47(6-7), pp.449-464.
  • Li, X., Krysiak-Baltyn, K., Richards, L., Jarrold, A., Stevens, G.W., Bowser, T., Speight, R.E. and Gras, S.L., (2020). High-efficiency biocatalytic conversion of thebaine to codeine. ACS omega, 5(16), pp.9339-9347.
  • Richards, L., Lutz, A., Chalmers, D.K., Jarrold, A., Bowser, T.A., Stevens, G.W. and Gras, S.L., (2019). Production of metabolites of the anti-cancer drug noscapine using a P450BM3 mutant library. Biotechnology Reports, 24, p.e00372.
  • Guo, L., Winzer, T., Yang, X., Li, Y., Ning, Z., He, Z., Teodor, R., Lu, Y., Bowser, T.A., Graham, I.A. and Ye, K., (2018). The opium poppy genome and morphinan production. Science, 362(6412), pp.343-347.
  • Winzer, T., Kern, M., King, A.J., Larson, T.R., Teodor, R.I., Donninger, S.L., Li, Y., Dowle, A.A., Cartwright, J., Bates, R. Ashford, D., Thomas, J., Walker, C., Bowser, T.A., Graham, I.A., (2015). Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein. Science, 349(6245), pp.309-312.
  • Winzer, T., Kern, M., King, A.J., Larson, T.R., Teodor, R.I., Donninger, S.L., Li, Y., Dowle, A.A., Cartwright, J., Bates, R. Ashford, D., Thomas, J., Walker, C., Bowser, T.A., Graham, I.A., (2015). Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein. Science, 349(6245), pp.309-312.
  • Hansen, E.H., Møller, B.L., Koch, G., Bünner, C.M., Kristensen, C., Jensen, O.R., Motawia, M.S., Olsen, C.E., Okkels, F.T., and Hansen, J.(2009). De novo biosynthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker’s yeast (Saccharomyces cerevisiae).  Env. Microbiol, 75(9), pp.2765-2774.
  • Hansen, E.H., Osmani S.A., Kristensen, C., Møller, B.L. and Hansen, J.(2009). Substrate specificities of family 1 UGTs gained by domain swapping. Phytochemistry, 70(4), pp.473-482.
  • Olesen, K., Felding, T., Gjermansen, C. and Hansen, J.(2003). The dynamics of the S. carlsbergensis brewing yeast transcriptome during a production scale lager beer fermentation. FEMS Yeast Res, 2(4), pp.563-573.
  • Hansen, J.and M.C. Kielland-Brandt. (1996). Inactivation of MET10 in brewer’s yeast specifically increases SO2 formation during beer production. Nature Biotechnol, 14(11), pp.1587-1591.