Prostaglandins
Sustainable, scalable, and cost-effective manufacturing
Prostaglandins are powerful lipid-based molecules used as active pharmaceutical ingredients (APIs) in a range of therapies, including reproductive health, glaucoma and cardiovascular treatment. Our proprietary microbial production platform enables sustainable, scalable, and cost-effective manufacturing of high-purity prostaglandins, offering a reliable, easily scalable, and cost-competitive alternative to traditional chemical synthesis. In the near term, we expect to supply PGF2α (dinoprost) as well as PGE1 (alprostadil) and PGE2 (dinoprostone)—available both as precursors/intermediates for downstream derivatization and as final APIs, depending on customer needs.
In parallel, our platform supports novel, differentiated routes to semi-synthetic prostaglandin APIs, enabling efficient and cost competitive access to clinically important APIs such as latanoprost, bimatoprost, carboprost and related compounds.
Buprenorphine
Safer, evidence-based maintenance therapy.
Buprenorphine is a partial opioid agonist used as a core medication in the treatment of opioid use disorder (OUD). By reducing cravings and withdrawal symptoms while having a ceiling effect on respiratory depression, it supports safer, evidence-based maintenance therapy.
Buprenorphine is also widely used in combination therapy with naloxone to help deter misuse and to support OUD treatment programs.
River Stone Biotech produces Buprenorphine via a novel mixed biological and chemical synthesis in accord with the USP and EP Pharmacopeia.
Naloxone
Life-saving medication that rapidly reverses opioid overdose
Naloxone is an opioid antagonist and a life-saving medication that rapidly
reverses opioid overdose – the leading cause of accidental deaths in the US. It
may also be combined with Buprenorphine as a combination therapy for
treating OUD.
River Stone Biotech produces Naloxone Hydrochloride dihydrate in accord with
the USP and EP Pharmacopoeia.
Naltrexone
For treatment of alcohol use disorder
Naltrexone is a medication used in the treatment of alcohol use disorder and opioid use disorder. It is also used in combination with Bupropion as a therapeutic for obesity.
River Stone Biotech produces Naltrexone hydrochloride in accord with the USP and EP Pharmacopoeia.
Other Nal products
River Stone Biotech is also exploring utilizing its platform to produce other Nal-type molecules and compounds that show therapeutic potential, including: Nalmefene, Nalbuphine, Methylnaltrexone and Naloxegol.
River Stone Biotech uses the power of synthetic biology to simplify the production of alkaloid molecules, initially Buprenorphine, Naloxone and Naltrexone. Whereas current industry standards use a complex chemistry process to generate these products, River Stone has discovered a synthetic pathway that uses a novel intermediate to remove several synthetic steps, producing APIs faster and cheaper.
Other products
River Stone Biotech’s platform is designed to extend beyond our core product categories, enabling efficient, scalable manufacturing of a wide range of specialty molecules for both pharmaceutical (API and intermediate) and non-pharmaceutical applications. Examples of the breadth of our capabilities include lysergic acid (an ergot alkaloid scaffold used as an advanced intermediate), nootkatone (a bio-based insect repellent ingredient), vanillin (a widely used flavor and fragrance molecule), and psilocybin (an alkaloid of interest for regulated clinical and research applications).
